Steady-state indirect bilirubin level in sickle cell anemia: A comparative hospital-based cross-sectional study

Background: The major forms of sickle cell disease are characterized by hemolysis. extent this hemolysis may itself depend on the form even in steady-state. This study aims to compare indirect bilirubin level between homozygous and beta plus anemia (SAFA2) steady-state conditions. Material methods: Fifty subjects each forms, were enrolled a comparative hospital-based cross-sectional from April 2008 May at laboratory university hospital Yopougon, Ivory Coast. Subjects awaiting their visits selected database patients regularly followed clinical hematology department Yopougon University Hospital. During visits, socio-demographic data collected, blood sample was also taken carry out biological examinations. Blood count testing performed using Sysmex Kx-21™ BioMérieux KONELAB-20™, respectively. Data analysis software Statistical Product Service Solutions version 12.0. Shapiro test used verify normality Student t-test for comparison parametric means or Mann-Whitney’s independent none-parametric data. Pearson Chi square tests Yate’s correction continuity where first not appropriate. threshold statistical significance set p ≤ 0.05. Results: median Hb higher SAFA2 compared SSFA2 10.7 g/dL [IQR = 8] vs 7.3 7]; < 0.001. In contrast, lower 5.6 μmol/L 10] 15.1 13], ratio these two medians shows that 2.7 times less than Out one hundred subjects, hyperbilirubinemia defined as > 14 men women 79.2% 20.8%, 0.01 whereas age groups associated hyperbilirubinemia, 0.4. Conclusion: Our suggest is marked chronic must be into account when it comes give comprehensive care subjects.